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Presentation synopsis:
Cell metabolism and HIV pathogenesis

Cellular metabolism plays a critical role in regulating T-cell immunity. T cell functions, such as proliferation, secretion of cytokines and cell survival, are supported through different engagement of metabolic pathways. We have found that HIV exploits the metabolic requirements of CD4+ T-cells to establish infection, identifying a vulnerability to target the infected cells. On the other hand, we have observed that while natural HIV controllers establish optimal HIV-specific CD8+ T-cell memory characterized by metabolic plasticity, non-controllers have skewed memory responses with strict glucose dependency. Interestingly, metabolic reprogramming of CD8+ T cells from non-controllers can enhance their antiviral potential. Overall, our results establish a link between cell metabolism and both HIV-specific CD8+ T-cell functionality and the establishment and persistence of CD4+ T-cell reservoirs and may provide valuable leads to tackle HIV infection.

This work was conducted with funds from ANRS, MSDAVENIR, amfAR, Sidaction and from the European Union (EU)’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 706871.

Speaker biography:

Dr Sáez-Cirión received his PhD degree from the University of the Basque Country in Spain and did a postdoctoral training at the FDA Center for Biologics Evaluation and Research in Bethesda. In 2003, he joined the Institut Pasteur where he is now Associate Professor and Team Leader at the HIV, Inflammation and Persistence Unit. Dr Sáez-Cirión is the Co-coordinator of the ANRS RHIVIERA consortium on HIV remission and the ANRS VISCONTI study. He is the president of the scientific and medical committee of Sidaction.

His work is currently focused on understanding natural mechanisms associated to control of HIV/SIV infection and progression to AIDS. In particular, he studies the role of intrinsic and adaptive immunity and the impact of viral reservoirs in different models of spontaneous or induced control of viremia in the absence of antiretroviral therapy.


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