His primary clinical research interest focuses on HIV infection, initially the treatment of AIDS-related opportunistic infections, and then the treatment of HIV infection. He has been involved in a number of studies assessing new drugs or new strategies for the treatment of HIV infection. A cohort of more than 4,000 patients with HIV infection is followed in his department.
He is also a member of the French National Institute of Health and Medical Research (INSERM) U944 team at the Saint-Louis Hospital investigating cell biology of viral infections. He has authored many papers in a wide variety of scientific journals, including Clinical Infectious Diseases, the Journal of Infectious Diseases, the New England Journal of Medicine, the Lancet and AIDS.
He is also involved in the French National Agency for AIDS Research (ANRS), where he chaired the clinical trial group for the last 12 years before becoming a member of the ANRS strategic committee. More recently, Professor Molina has broadened his field of interest to the prevention of HIV infection with antiretrovirals and has led the ANRS IPERGAY pre-exposure prophylaxis (PrEP) trial in MSM. A cohort of more than 2,000 people on PrEP is followed in his unit, and a new ANRS PrEP study (ANRS Prevenir) is implemented in the Paris region to contain the HIV epidemic among gay men.