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Presentation synopsis:

Inflammation, the microbiome and HIV

Virtually all chronically HIV-1-infected subjects are able to suppress HIV-1 replication with current antiretroviral therapy. This improves their life expectancy and quality of life, but does not prevent them from developing diseases associated with chronic inflammation. In Western societies, in fact, the main clinical problems in chronically HIV-1 infected subjects either derive from late HIV-1 diagnosis or from premature aging. We will review recent evidence showing a dose-effect association between lower nadir CD4+ T-cell counts and gut dysbiosis, discuss when might dysbiosis actually initiate following HIV-1 infection, and will evaluate the potential diagnostic and therapeutic implications of gut dysbiosis in people living with HIV.

Speaker biography:

Roger Paredes, MD, PhD, is Section Chief at the Infectious Diseases Service,  Hospital Germans Trias i Pujol and Head of the Microbial Genomics Group at the IrsiCaixa AIDS Research Institute, Badalona, Catalonia, Spain.

Roger Paredes obtained an MD, PhD degree in Medicine and Surgery from the Autonomous University of Barcelona (UAB). He specialised in HIV resistance at the Brigham & Women’s Hospital in Boston and Harvard Medical School.

His team has demonstrated the clinical utility of HIV-1 deep sequencing in both high- and low-income countries. Dr Paredes is member of the WHO HIV Drug Resistance Strategy (ResNet) Steering Committee and the International Antiviral Society-USA, which annually produces the IAS-USA list of HIV-1 drug resistance mutations, used worldwide and is Vice-Chair of the EuroSIDA Study. His group at irsiCaixa is presently leading pioneering research into the role of the gut microbiome in the pathogenesis of HIV infection and chronic inflammation. Dr Paredes combines his research work at irsiCaixa with a senior medical appointment at the HIV Unit of the Germans Trias i Pujol University Hospital in Badalona, Catalonia, Spain.


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