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Presentation synopsis:

Phylogenetics as a tool in HIV research 

Phylogenetic approaches have provided key insights into the epidemiology, pathogenesis, and immunology of HIV. Starting from basic molecular epidemiology approaches to characterize the HIV transmission network, I will discuss how this information can be used to assess and guide prevention efforts and how phylogenetic approaches can be augmented by mathematical modelling. Finally, I will discuss how the distribution of patients on the HIV phylogeny can inform on the interaction of HIV with coinfections and on the impact of viral genetic factors on phenomena ranging from HIV set-point virus load to the latent reservoir and broadly neutralizing antibody responses.

Speaker biography:

Roger Kouyos studied physics at ETH Zurich from 2001-2004 followed by a PhD 2008 in mathematical and computational biology, also at ETHZ. Subsequently, he conducted research on HIV epidemiology at the University Hospital Zurich, a postdoc at ETHZ on antibiotic resistance, and a Swiss-National-Science-Foundation (SNSF) fellowship at the University of Princeton on infectious diseases dynamics and immunometrics.

He returned in 2012 to the University of Zurich as SNSF-funded junior group leader to work on the molecular and computational epidemiology of HIV and coinfections, and is since 2015 an SNSF-Starting-Grant professor at UZH. His current research focuses on computational and molecular approaches to infection and immunity with topics ranging from using transmission networks and mathematical models to assess public health interventions to studying the viral reservoir of HIV and the elicitation of broadly neutralizing antibodies.


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